Orthopedic

orthopedic1

Definition of Musculoskeletal System Disorders

Disorders of the musculoskeletal system may result from hereditary, congenital, or acquired pathologic processes. Impairments may result from infectious, inflammatory, or degenerative processes, traumatic or developmental events, or neoplastic, vascular, or toxic/metabolic diseases.

Loss of function may be due to bone or joint deformity or destruction from any cause; miscellaneous disorders of the spine with or without radiculopathy or other neurological deficits; amputation; or fractures or soft tissue injuries, including burns, requiring prolonged periods of immobility or convalescence. Regardless of the cause(s) of a musculoskeletal impairment, functional loss for purposes of these listings is defined as the inability to ambulate effectively on a sustained basis for any reason, including pain associated with the underlying musculoskeletal impairment, or the inability to perform fine and gross movements effectively on a sustained basis for any reason, including pain associated with the underlying musculoskeletal impairment. Some of the common impairments are:

  • Arthritis
  • Rheumatoid arthritis
  • Osteoporosis
  • Osteoarthritis
  • Kyphosis
  • Scoliosis
  • Muscular dystrophy
  • Bone fractures
  • Fibromyalgia
  • Paget’s disease
  • Sports injuries

(For more information go to: http://www.merckmanuals.com/professional/musculoskeletal_and_connective_tissue_disorders.html)


ECR Center expedites every aspect of a musculoskeletal system drug trial. It combines global experience in II, III and IV Phases of musculoskeletal system drug development with expertise in musculoskeletal system imaging, laboratory (including PK/PD and Biomarkers) IVRS, central data management, electronic data capture and regulatory issues. Our clinical trial experience includes the following musculoskeletal system indications:

  • Arthritis
  • Rheumatoid Arthritis
  • Infectious Arthritis
  • Gouty Arthritis
  • Arthritis
  • Bone Diseases
  • Cartilage Diseases
  • Metabolic Bone Diseases