Definition of Digestive System Disorders

Disorders of the digestive system include gastrointestinal hemorrhage, hepatic (liver) dysfunction, inflammatory bowel disease, short bowel syndrome, and malnutrition. They may also lead to complications, such as obstruction, or be accompanied by manifestations in other body systems.

Functional disorders are those in which the bowel looks normal but doesn't work properly. They are the most common problems affecting the colon and rectum, and include constipation and irritable bowel syndrome (IBS). The primary causes for functional disorders include:

  • Eating a diet low in fiber
  • Not getting enough exercise
  • Traveling or other changes in routine
  • Eating large amounts of dairy products
  • Being stressed
  • Resisting the urge to have a bowel movement
  • Resisting the urge to have bowel movements due to pain from hemorrhoids
  • Overusing laxatives (stool softeners) that, over time, weaken the bowel muscles
  • Taking antacid medicines containing calcium or aluminum
  • Taking certain medicines (especially antidepressants, iron pills, and strong pain medicines such as narcotics)
  • Being pregnant

(For more information go to: http://www.merckmanuals.com/professional/gastrointestinal_disorders.html)

ECR Center expedites every aspect of a gastroenterology drug trial. It combines global experience in II, III and IV Phases of gastroenterology drug development with expertise in digestive system imaging, laboratory (including PK/PD and Biomarkers) IVRS, central data management, electronic data capture and regulatory issues. Our clinical trial experience includes the following gastroenterology indications:

  • Acute Pancreatitis
  • Colorectal Conditions
  • Constipation
  • Crohn’s Disease
  • Inflammatory Bowel Disease
  • Irritable Bowel Disease
  • Diarrhea
  • Dyspepsia
  • Gastroenteritic Infections
  • Gastroesophageal Reflux
  • Liver Cirrhosis
  • Esophagitis
  • Ulcerative Colitis
  • Biliary Tract Diseases
  • Appendicitis
  • Cholelithiasis