Definition of Cardiovascular Disorders

Any disorder that affects the proper functioning of the heart or the circulatory system (that is, arteries, veins, capillaries, and the lymphatic drainage). The disorder can be congenital or acquired. Cardiovascular impairment results from one or more of four consequences of heart disease:

  • Chronic heart failure or ventricular dysfunction.
  • Discomfort or pain due to myocardial ischemia, with or without necrosis of heart muscle.
  • Syncope, or near syncope, due to inadequate cerebral perfusion from any cardiac cause, such as obstruction of flow or disturbance in rhythm or conduction resulting in inadequate cardiac output.
  • Central cyanosis due to right-to-left shunt, reduced oxygen concentration in the arterial blood, or pulmonary vascular disease.

Disorders of the veins or arteries (for example, obstruction, rupture, or aneurysm) may cause impairments of the lower extremities (peripheral vascular disease), the central nervous system, the eyes, the kidneys, and other organs.

(For more information go to: http://www.merckmanuals.com/professional/cardiovascular_disorders.html)

ECR Center expedites every aspect of a cardiology drug trial. It combines global experience in II, III and IV Phases of cardiology drug development with expertise in EKG, Doppler’s, imaging, laboratory (including PK/PD and Biomarkers) IVRS, central data management, electronic data capture and regulatory issues. Our clinical trial experience includes the following cardiology indications:

  • Acute coronary syndrome (ACS)
  • Anticoagulation
  • Angina
  • Arrhythmias
  • Atherosclerosis
  • Atrial Fibrillation
  • Cardiovascular Prevention
  • Cerebrovascular Disease
  • Congestive Heart Failure
  • Coronary Artery Disease
  • Hypertension
  • Myocardial Infarction
  • Peripheral Artery Disease
  • Pulmonary Artery Hypertension
  • Stroke
  • Thrombosis